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KMID : 0882420150880010078
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Korean Journal of Medicine
2015 Volume.88 No. 1 p.78 ~ p.82
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A Case of Pituitary Macroadenoma Concurrently Diagnosed in a Patient Undergoing Antipsychotic Treatment
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Kim Bong-Sun
Kim Joo-Sung
Ryu Hyong-Kyu
Park Jin-Woong
Hyun Sun-A
Kang Je-Wook
Choi Yong-Jun
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Abstract
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Antipsychotics are the drug of choice for patients with schizophrenia, but they can induce hyperprolactinemia and growth of pituitary adenomas by blocking dopamine 2 receptors in the pituitary gland. In contrast, the medical treatment for a prolactinoma is a dopamine agonist. Therefore, managing a patient concurrently diagnosed with a prolactinoma and psychosis is challenging. We describe a patient with schizophrenia who was diagnosed with a prolactinoma. We changed his neuroleptic to quetiapine and prescribed bromocriptine for the prolactinoma. As a result, the patient was successfully treated with a dopamine agonist and antipsychotic without psychotic exacerbation. Our case suggests that dopamine agonists can be administrated to patients with schizophrenia and a prolactinoma without adversely affecting their psychopathological status.
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KEYWORD
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Prolactinoma, Bromocriptine, Antipsychotic agents
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